Adiponectin in Type II Diabetes Mellitus

Abstract Background: Diabetes mellitus is a chronic disorder characterized by impaired metabolism of glucose and lipids due to defect in insulin secretion or action. The association obesity with development type 2 diabetes may be partly mediated altered adipokines adipose tissues which contribute obesity. It has been reported that reduction plasma adiponectin level related the elevation resistance. Aim Study: This study aimed evaluate patients mellitus. Subjects Methods: current examined sixty diabetic (type 2) BMI from 30-40kg/m2 20 age sex matched healthy controls 20-25 kg/m2 . Statistical Analysis: data were tested for normality using Anderson-Darling test homogeneity variances prior further statistical analysis. Results: Adiponectin was significantly lower all compared controls. Lipid profile showing higher levels than In patients, positively correlated High Density Lipoprotein Cholesterol (HDL-C), while it negatively HbA1C, cholesterol, Low (LDL-C), triglyceride micro-albuminuria. Conclusion: plays an important role patho-physiology resistance, diabetes, lipid metab-olism. Reduction resistance associated milletus II. represents very step understand mechanism obesity-induced atherosclerosis. contrast other known adipocyte-derived hormones are generally increased obesity, concentrations serum inversely triglycerides HbA1c DM patients. Decreased obese individuals. fact together promising results experimental studies suggests possibility replacement might become new pharmacological approach treatment and/or atherosclerosis so our recommendations monitoring good predictor glycemic control should used follow-up. Insulin measured effect on level.